Journal
NATURE REVIEWS MICROBIOLOGY
Volume 10, Issue 3, Pages 213-225Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2733
Keywords
-
Categories
Funding
- UK Medical Research Council
- UK Biotechnology and Biological Sciences Research Council
- MRC [G0700151] Funding Source: UKRI
- Medical Research Council [G0700151] Funding Source: researchfish
Ask authors/readers for more resources
Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their own secretion: an amino-terminal signal peptide to mediate translocation across the inner membrane, a central passenger domain that is the secreted functional moiety, and a channel-forming carboxyl terminus that facilitates passenger domain translocation across the outer membrane. However, recent discoveries of common structural themes, translocation intermediates and accessory interactions have challenged the perceived simplicity of autotransporter secretion. Here, we discuss how these studies have led to an improved understanding of the mechanisms responsible for autotransporter biogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available