Journal
NATURE REVIEWS MICROBIOLOGY
Volume 10, Issue 6, Pages 431-438Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2779
Keywords
-
Categories
Funding
- Wellcome Trust [082601/Z/07/Z]
- Wellcome Trust [082601/Z/07/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
During their life cycle, trypanosomes must overcome conflicting demands to ensure their survival and transmission. First, they must evade immunity without overwhelming the host. Second, they must generate and maintain transmission stages at sufficient levels to allow passage into their tsetse vector. Finally, they must rapidly commit to onward development when they enter the tsetse fly. On the basis of recent quantification and modelling of Trypanosoma brucei infection dynamics, we propose that the interplay between immune evasion and development achieves both infection chronicity and transmissibility. Moreover, we suggest that a novel form of bistable regulation ensures developmental commitment on entry into the tsetse fly midgut.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available