Journal
NATURE REVIEWS MICROBIOLOGY
Volume 10, Issue 3, Pages 203-212Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2720
Keywords
-
Categories
Funding
- US National Institutes of Health [2 R01 AI44212]
- University of Michigan, Ann Arbor, USA
Ask authors/readers for more resources
During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments, using mechanisms beyond the direct regulation of RNAP activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available