Journal
NATURE REVIEWS MICROBIOLOGY
Volume 11, Issue 1, Pages 14-19Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2918
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Funding
- NIAID NIH HHS [U01 AI095776, R01 AI078965, R01 AI048090] Funding Source: Medline
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Mucosal-associated invariant T (MAIT) cells are a unique T cell subset in mammals. They are present at high frequencies at mucosal tissue sites and have an intrinsic capacity to respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites. The striking evolutionary conservation in both the MR1 molecule and the MAIT T cell receptor suggests that strong selective pressures maintain this T cell pattern recognition system which detects microbial infection.
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