Journal
NATURE REVIEWS MICROBIOLOGY
Volume 9, Issue 9, Pages 647-657Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2632
Keywords
-
Categories
Funding
- US National Institutes of Health [RO1 AI074825]
Ask authors/readers for more resources
Tailed bacteriophages use nanomotors, or molecular machines that convert chemical energy into physical movement of molecules, to insert their double-stranded DNA genomes into virus particles. These viral nanomotors are powered by ATP hydrolysis and pump the DNA into a preformed protein container called a procapsid. As a result, the virions contain very highly compacted chromosomes. Here, I review recent progress in obtaining structural information for virions, procapsids and the individual motor protein components, and discuss single-molecule in vitro packaging reactions, which have yielded important new information about the mechanism by which these powerful molecular machines translocate DNA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available