Journal
NATURE REVIEWS MICROBIOLOGY
Volume 9, Issue 12, Pages 860-875Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2655
Keywords
-
Categories
Funding
- US National Institutes of Health
- Science Foundation Ireland
- Irish Health Research Board
Ask authors/readers for more resources
Viruses are fully reliant on the translation machinery of their host cells to produce the polypeptides that are essential for viral replication. Consequently, viruses recruit host ribosomes to translate viral mRNAs, typically using virally encoded functions to seize control of cellular translation factors and the host signalling pathways that regulate their activity. This not only ensures that viral proteins will be produced, but also stifles innate host defences that are aimed at inhibiting the capacity of infected cells for protein synthesis. Remarkably, nearly every step of the translation process can be targeted by virally encoded functions. This Review discusses the diverse strategies that viruses use to subvert host protein synthesis functions and regulate mRNA translation in infected cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available