Journal
NATURE REVIEWS MICROBIOLOGY
Volume 9, Issue 8, Pages 590-603Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2613
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Funding
- US National Institute of Allergy and Infectious Disease (NIAID) [R01AI046954, U01AI070469, U19AI083025, U54AI057158, P01AI058113, HHSN266200700010C]
- Center for Research of Influenza Pathogenesis (CRIP)
- W. M. Keck Foundation
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Influenza A viruses are zoonotic pathogens that continuously circulate and change in several animal hosts, including birds, pigs, horses and humans. The emergence of novel virus strains that are capable of causing human epidemics or pandemics is a serious possibility. Here, we discuss the value of surveillance and characterization of naturally occurring influenza viruses, and review the impact that new developments in the laboratory have had on our understanding of the host tropism and virulence of viruses. We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years.
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