Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state

Despite major treatment and prevention efforts, millions of new typhoid infections occur worldwide each year. For a subset of infected individuals, Salmonella enterica subsp. enterica serovar Typhi colonizes the gall bladder and remains there long after symptoms subside, serving as a reservoir for the further spread of the disease. In this Progress article, we explore recent advances in our understanding of the mechanisms by which Salmonella spp. - predominantly S. Typhi - colonize and persist in the human gall bladder.