Journal
NATURE REVIEWS MICROBIOLOGY
Volume 8, Issue 8, Pages 541-551Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2393
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Funding
- NIAID NIH HHS [R21 AI067654, R21 AI067654-01A1] Funding Source: Medline
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The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.
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