Journal
NATURE REVIEWS MICROBIOLOGY
Volume 8, Issue 6, Pages 413-422Publisher
NATURE RESEARCH
DOI: 10.1038/nrmicro2317
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Funding
- Swedish Research Council VR-M
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (Formas)
- Swedish International Development Cooperation Agency (SIDA)
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The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.
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