Journal
NATURE REVIEWS MICROBIOLOGY
Volume 8, Issue 4, Pages 281-289Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2278
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Funding
- Biotechnology and Biological Sciences Research Council [BB/E021611/1]
- Engineering and Physical Sciences Research Council
- BBSRC [BB/E022367/1, BB/E021611/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E022367/1] Funding Source: researchfish
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Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.
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