Journal
NATURE REVIEWS MICROBIOLOGY
Volume 9, Issue 2, Pages 131-137Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2478
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Funding
- Dutch Technology Foundation (STW), The Netherlands Organisation for Scientific Research (NWO)
- Ministry of Economic Affairs [STW 10463]
- NWO-Vidi
- University of Groningen, Netherlands
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One of the most promising applications of synthetic biology is the biosynthesis of new drugs from secondary metabolites. Here, we survey a wide range of strategies that control the activity of biosynthetic modules in the cell in space and time, and illustrate how these strategies can be used to design efficient cellular synthetic production systems. Re-engineered versions of secondary metabolite biosynthetic pathways identified from any genomic sequence can then be inserted into these systems in a plug-and-play fashion.
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