Journal
NATURE REVIEWS MICROBIOLOGY
Volume 8, Issue 10, Pages 731-741Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2406
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Funding
- US National Institutes of Health
- National Library of Medicine
- Edward Penley Abraham Trust
- NATIONAL LIBRARY OF MEDICINE [ZIALM000061, ZIALM000073] Funding Source: NIH RePORTER
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Recently a novel cell division system comprised of homologues of eukaryotic ESCRT-III (endosomal sorting complex required for transport III) proteins was discovered in the hyperthermophilic crenarchaeote Sulfolobus acidocaldarius. On the basis of this discovery, we undertook a comparative genomic analysis of the machineries for cell division and vesicle formation in Archaea. Archaea possess at least three distinct membrane remodelling systems: the FtsZ-based bacterial-type system, the ESCRT-III-based eukaryote-like system and a putative novel system that uses an archaeal actin-related protein. Many archaeal genomes encode assortments of components from different systems. Evolutionary reconstruction from these findings suggests that the last common ancestor of the extant Archaea possessed a complex membrane remodelling apparatus, different components of which were lost during subsequent evolution of archaeal lineages. By contrast, eukaryotes seem to have inherited all three ancestral systems.
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