Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 12, Pages 864-874Publisher
NATURE RESEARCH
DOI: 10.1038/nrmicro2239
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Funding
- Training Program in Microbiology for Infectious Diseases [T32 AI007161]
- National Institute of Allergy and Infectious Diseases [R01 AI079709]
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Plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine has led to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of treatment against malaria. ACTs comprise semisynthetic artemisinin derivatives paired with distinct chemical classes of longer acting drugs. These artemisinins are exceptionally potent against the pathogenic asexual blood stages of Plasmodium parasites and also act on the transmissible sexual stages. These combinations increase the rates of clinical and parasitological cures and decrease the selection pressure for the emergence of antimalarial resistance. This Review article discusses our current knowledge about the mode of action of ACTs, their pharmacological properties and the proposed mechanisms of drug resistance.
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