Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 12, Pages 845-855Publisher
NATURE RESEARCH
DOI: 10.1038/nrmicro2236
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Funding
- Bill and Melinda Gates Foundation
- Wellcome Trust
- National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) [RO1 HL075845]
- MRC [MC_U117588499, MC_U117581288] Funding Source: UKRI
- Medical Research Council [MC_U117581288, MC_U117588499] Funding Source: researchfish
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Immunological tests provide evidence of latent tuberculosis in one third of the global population, which corresponds to more than two billion individuals. Latent tuberculosis is defined by the absence of clinical symptoms but carries a risk of subsequent progression to clinical disease, particularly in the context of co-infection with HIV. In this Review we discuss the biology of latent tuberculosis as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide microenvironments with differential ability to support or suppress the persistence of viable bacteria. We then show how this model can be used to develop a rational programme to discover effective drugs for the eradication of M. tuberculosis infection.
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