Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 6, Pages 424-438Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2146
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Funding
- National Institutes of Health [R01 GM070589-01]
- National Science Foundation [IOB-0618409, IOS-0822257]
- National Oceanic and Atmospheric Administration [NA05NMF4571243]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070589] Funding Source: NIH RePORTER
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Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous ('self') carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and effector factors in innate immunity. Some parasites subvert the recognition roles of the vector or host galectins to ensure successful attachment or invasion. This Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses.
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