Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 11, Pages 822-827Publisher
NATURE RESEARCH
DOI: 10.1038/nrmicro2202
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Funding
- Welch Foundation [Q-1698]
- Public Health Service grants [GM084003, DP2OD004433, GM64671]
- US National Institutes of Health
- National Science Foundation CAREER award [MCB-0448186]
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Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in the 'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to accommodate changes in nutrient availability stemmed almost entirely from elegant physiological studies completed in the 1960s. In this Opinion article we summarize recent groundbreaking work in this area and discuss potential mechanisms by which nutrient availability and metabolic status are coordinated with cell growth, chromosome replication and cell division.
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