Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 6, Pages 439-450Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2147
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Funding
- National Institutes of Health (USA) [PO1 AI060699, RO1 NS36592, T32 AI007533]
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Although coronaviruses were first identified nearly 60 years ago, they only received notoriety in 2003 when one of their members was identified as the aetiological agent of severe acute respiratory syndrome. Previously these viruses were known to be important agents of respiratory and enteric infections of domestic and companion animals and to cause approximately 15% of all cases of the common cold. This Review focuses on recent advances in our understanding of the mechanisms of coronavirus replication, interactions with the host immune response and disease pathogenesis. It also highlights the recent identification of numerous novel coronaviruses and the propensity of this virus family to cross species barriers.
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