Journal
NATURE REVIEWS MICROBIOLOGY
Volume 8, Issue 1, Pages 8-14Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2266
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Funding
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- Horserace Betting Levy Board
- Biotechnology and Biological Sciences Research Council [BB/G002797/1, BB/C005503/1, BB/H003916/1] Funding Source: researchfish
- Medical Research Council [G1000133, G0400007] Funding Source: researchfish
- BBSRC [BB/H003916/1, BB/G002797/1] Funding Source: UKRI
- MRC [G0400007, G1000133] Funding Source: UKRI
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Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.
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