Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 6, Pages 460-466Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2133
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Funding
- National Institutes of Health
- National Science Foundation
- National Defense Science and Engineering
- National Institutes of Health [R01GM081617]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM081617] Funding Source: NIH RePORTER
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Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.
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