Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 12, Pages 875-886Publisher
NATURE RESEARCH
DOI: 10.1038/nrmicro2249
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Funding
- US National Institutes of Health [R01AI0624273, R01AI075096, R01 DE14666]
- National Science Foundation [MCB-0719126]
- March of Dimes
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The many different mechanisms that fungi use to transmit and share genetic material are mediated by a broad range of chromosome and nuclear dynamics. The mechanics underlying nuclear migration are well integrated into detailed models, in which the forces supplied by plus- and minus-end-directed microtubule motors position and move the nucleus in a cell. Although we know much about how cells move nuclei, we know much less about why the cell invests in so many different nuclear 'dances'. Here, we briefly survey the available models for the mechanics of nuclear migration in fungi and then focus on examples of how fungal cells use these nuclear dances-the movement of intact nuclei in and between cells-to control the integrity, ploidy and assortment of specific genomes or individual chromosomes.
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