Journal
NATURE REVIEWS MICROBIOLOGY
Volume 7, Issue 11, Pages 798-812Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2223
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Funding
- European Union (EUROPRISE)
- Instituto de Salud Carlos III [RETIC RD06/0006]
- Comunidad de Madrid (VIRHOST Network)
- FIPSE (Fundacion para la investigacion y prevencion del SIDA en Espana)
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HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.
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