Journal
NATURE REVIEWS MICROBIOLOGY
Volume 6, Issue 9, Pages 657-666Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1955
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Funding
- NIAID NIH HHS [R01 AI075068-01, R01 AI075068] Funding Source: Medline
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The ability of the human body to play host to bacterial pathogens has been studied for more than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are necessary for growth and survival, yet relatively little is understood about the in vivo physiology and metabolism of most human pathogens. This Review discusses how in vivo carbon sources can affect disease and highlights the concept that carbon metabolic pathways provide viable targets for antibiotic development.
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