Journal
NATURE REVIEWS MICROBIOLOGY
Volume 6, Issue 11, Pages 838-850Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2009
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Funding
- Royal Society
- BBSRC
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [EGH17741] Funding Source: researchfish
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In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence.
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