Journal
NATURE REVIEWS MICROBIOLOGY
Volume 6, Issue 7, Pages 541-552Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1930
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Funding
- Medical Research Council [G0700844] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G0700844] Funding Source: UKRI
- Medical Research Council [G0700844] Funding Source: researchfish
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Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosis and could be partly caused by the viruses themselves. Understanding how iron metabolism and viral infection interact might suggest new methods to control disease.
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