Journal
NATURE REVIEWS MICROBIOLOGY
Volume 6, Issue 9, Pages 667-673Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1960
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Funding
- NIAID NIH HHS [R21 AI076156-01, R21 AI076156, AI076156] Funding Source: Medline
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Numerous fungal species respond to contact with a surface by undergoing differentiation. Contact between plant pathogenic fungi and a surface results in the elaboration of the complex structures that enable invasion of the host plant, and for the opportunistic human pathogen Candida albicans, contact with a semi-solid surface results in invasive growth into the subjacent material. The ability to sense contact with an appropriate surface therefore contributes to the ability of these fungi to cause disease in their respective hosts. This Review discusses molecular mechanisms of mechanosensitivity, the proteins involved, such as mechanosensitive ion channels, G-protein-coupled receptors and integrins, and their putative roles in fungal contact sensing.
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