Journal
NATURE REVIEWS GENETICS
Volume 15, Issue 8, Pages 556-570Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg3767
Keywords
-
Categories
Funding
- US National Human Genome Research Institute [U01HG006517, R01HG005690, R01HG007069]
- US National Cancer Institute [R01CA180006]
Ask authors/readers for more resources
High-throughput DNA sequencing has revolutionized the study of cancer genomics with numerous discoveries that are relevant to cancer diagnosis and treatment. The latest sequencing and analysis methods have successfully identified somatic alterations, including single-nucleotide variants, insertions and deletions, copy-number aberrations, structural variants and gene fusions. Additional computational techniques have proved useful for defining the mutations, genes and molecular networks that drive diverse cancer phenotypes and that determine clonal architectures in tumour samples. Collectively, these tools have advanced the study of genomic, transcriptomic and epigenomic alterations in cancer, and their association to clinical properties. Here, we review cancer genomics software and the insights that have been gained from their application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available