Journal
NATURE REVIEWS GENETICS
Volume 15, Issue 12, Pages 783-796Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3796
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Funding
- French National Centre for Scientific Research (CNRS)
- University of Texas at Austin, USA
- Cancer Prevention Research Institute of Texas (CPRIT) [R116]
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Small molecules including various approved and novel cancer therapeutics - can operate at the genomic level by targeting the DNA and protein components of chromatin. Emerging evidence suggests that functional interactions between small molecules and the genome are non-stochastic and are influenced by a dynamic interplay between DNA sequences and chromatin states. The establishment of genonne-wide maps of small-molecule targets using unbiased methodologies can help to characterize and exploit drug responses. In this Review, we discuss how high-throughput sequencing strategies, such as ChIP-seq (chromatin immunoprecipitation followed by sequencing) and Chem-seq (chemical affinity capture and massively parallel DNA sequencing), are enabling the comprehensive identification of small-molecule target sites throughout the genonne, thereby providing insights into unanticipated drug effects.
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