Journal
NATURE REVIEWS GENETICS
Volume 16, Issue 1, Pages 57-66Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3832
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Funding
- European Research Council Advanced grant [ERC-AdG 294325-GeneNoiseControl]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) Vici award
- Human Frontier Science Program
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Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.
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