Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 8, Pages 585-594Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg3405
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Funding
- US National Institutes of Health [AG036039, HD068437, AG042190-01]
- Brain and Behavior Research Foundation
- UK Medical Research Council (MRC)
- American Asthma Foundation (AAF)
- BBMRI-NL
- Dutch government [NWO 184.021.007]
- European Union [259679]
- Netherlands CardioVascular Research Initiative from the Dutch Heart Foundation
- Dutch Federation of University Medical Centers
- Netherlands Organization for Health Research and Development
- Royal Netherlands Academy of Sciences
- Netherlands Consortium for Healthy Ageing in the framework of the Netherlands Genomics Initiative and the Netherlands Organization for Scientific Research [05060810]
- Medical Research Council [MR/K013807/1] Funding Source: researchfish
- MRC [MR/K013807/1] Funding Source: UKRI
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The epigenome has been heralded as a key 'missing piece' of the aetiological puzzle for complex phenotypes across the biomedical sciences. The standard research approaches developed for genetic epidemiology, however, are not necessarily appropriate for epigenetic studies of common disease. Here, we discuss the optimal execution of population-based studies of epigenetic variation, which will contribute to the emerging field of 'epigenetic epidemiology' and emphasize the importance of establishing a causal role in pathology for disease-associated epigenetic changes. We propose that improved understanding of the molecular mechanisms underlying human health and disease are best achieved through carrying out studies of epigenetics in populations as a part of an integrated functional genomics strategy.
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