Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 3, Pages 228-235Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3435
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Funding
- Swiss National Science Foundation
- European Research Council
- UK Medical Research Council (MRC)
- Wellcome Trust
- EUFP7
- MRC [MR/J001597/1, G1100226] Funding Source: UKRI
- Medical Research Council [G1100226, MR/J001597/1] Funding Source: researchfish
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Much attention has been given to the idea of transgenerational epigenetic inheritance, but fundamental questions remain regarding how much takes place and the impact that this might have on organisms. We asked five leading researchers in this area working on a range of model organisms and in human disease for their views on these topics. Their responses highlight the mixture of excitement and caution that surrounds transgenerational epigenetic inheritance and the wide gulf between species in terms of our knowledge of the mechanisms that may be involved.
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