Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 5, Pages 360-366Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3456
Keywords
-
Categories
Funding
- European Research Council
- Spanish Ministry of Economy and Competitiveness
- US Department of Health and Human Services
Ask authors/readers for more resources
Orthologues and paralogues are types of homologous genes that are related by speciation or duplication, respectively. Orthologous genes are generally assumed to retain equivalent functions in different organisms and to share other key properties. Several recent comparative genomic studies have focused on testing these expectations. Here we discuss the complexity of the evolution of gene-phenotype relationships and assess the validity of the key implications of orthology and paralogy relationships as general statistical trends and guiding principles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available