Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 9, Pages 608-617Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3543
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Funding
- US National Institute of Diabetes and Digestive and Kidney Diseases of the US National Institutes of Health [K01DK095003, P30DK056341]
- UK Biotechnology and Biological Sciences Research Council (BBSRC)
- Biotechnology and Biological Sciences Research Council [BB/C516936/1] Funding Source: researchfish
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Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that imprinted genes can be important contributors to complex trait variation. Therefore, to understand the genetic architecture and evolution of complex traits, including complex diseases and traits of agricultural importance, it is crucial to account for these parent-of-origin effects. Here, we discuss patterns of phenotypic variation associated with imprinting, evidence supporting its role in complex trait variation and approaches for identifying its molecular signatures.
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