Journal
NATURE REVIEWS GENETICS
Volume 15, Issue 1, Pages 49-55Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3624
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Funding
- US National Institute of Allergy and Infectious Diseases, the US National Institutes of Health [1R21AI100192]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI100192] Funding Source: NIH RePORTER
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The potential of bacterial whole-genome sequencing (WGS) to complement existing diagnostic infrastructures in clinical microbiology has been shown in proof-of-principle examples and extensively discussed. However, less attention has been drawn to bioinformatic challenges that are associated with the clinical adoption of WGS-based molecular diagnostics. This Perspective article discusses questions that are related to standard operating procedures, computational resource management, and data storage and integration in the context of recent developments in the sequencing and bioinformatics service markets.
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