Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 3, Pages 221-227Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3415
Keywords
-
Categories
Funding
- Royal Society
- Spanish Government (MEC)
Ask authors/readers for more resources
Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and nnutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available