Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 7, Pages 447-459Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3462
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB 960, FOR855]
- European Research Council (ERC grant 'sRNAs')
- Bavarian Genome Research Network (BayGene)
- Bavarian Systems-Biology Network (BioSysNet)
- European Union (grant 'ONCOMIRs')
- German Cancer Aid
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Small-RNA-guided gene regulation has emerged as one of the fundamental principles in cell function, and the major protein players in this process are members of the Argonaute protein family. Argonaute proteins are highly specialized binding modules that accommodate the small RNA component - such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) - and coordinate downstream gene-silencing events by interacting with other protein factors. Recent work has made progress in our understanding of classical Argonaute-mediated gene-silencing principles, such as the effects on mRNA translation and decay, but has also implicated Argonaute proteins in several other cellular processes, such as transcriptional regulation and splicing.
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