Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 4, Pages 288-295Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3458
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Funding
- US National Human Genome Research Institute [R01HG003988, U54HG006997]
- US Department of Energy, University of California [DE-AC02-05CH11231]
- Intramural Program of the US National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH)
- US National Institutes of Health [R01DK093972, R01HL114010]
- MRC [MC_PC_U127527202] Funding Source: UKRI
- Medical Research Council [MC_PC_U127527202] Funding Source: researchfish
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It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.
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