Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 3, Pages 168-178Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3404
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Funding
- European Research Council (ERC)
- MINECO [BFU2008-00365, BFU2011-26206]
- ERASysBio + ERANET project [EUI2009-04059 GRAPPLE]
- European Molecular Biology Organization (EMBO) Young Investigator Program
- EU Framework 7 project [277899 4DCellFate]
- EMBL/CRG Systems Biology Program
- ICREA Funding Source: Custom
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To what extent can variation in phenotypic traits such as disease risk be accurately predicted in individuals? In this Review, I highlight recent studies in model organisms that are relevant both to the challenge of accurately predicting phenotypic variation from individual genome sequences ('whole-genonne reverse genetics') and for understanding why, in many cases, this may be impossible. These studies argue that only by combining genetic knowledge with in vivo measurements of biological states will it be possible to make accurate genetic predictions for individual humans.
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