Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 10, Pages 692-702Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3604
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Funding
- US National Institutes of Health (NIH) Pioneer Award [DP1OD0644S]
- NIH [R01GM076637]
- US National Science Foundation Hominid grant [BCS0827436]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [0827436] Funding Source: National Science Foundation
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The recent availability of genomic data has spurred many genome-wide studies of human adaptation in different populations worldwide. Such studies have provided insights into novel candidate genes and pathways that are putatively involved in adaptation to different environments, diets and disease prevalence. However, much work is needed to translate these results into candidate adaptive variants that are biologically interpretable. In this Review, we discuss methods that may help to identify true biological signals of selection and studies that incorporate complementary phenotypic and functional data. We conclude with recommendations for future studies that focus on opportunities to use integrative genomics methodologies in human adaptation studies.
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