Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 9, Pages 645-660Publisher
NATURE RESEARCH
DOI: 10.1038/nrg3521
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Funding
- US National Institutes of Health (NIH)
- US National Science Foundation (NSF) [1R01100768-01A1, MCB1051826, MCB1026200]
- NSF dissertation improvement grant [DEB-1110607]
- NIH Genetics Training grant [T32 GM007197]
- US Department of Education GAANN Fellowship
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1051826] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1026200] Funding Source: National Science Foundation
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During the course of evolution, genomes acquire novel genetic elements as sources of functional and phenotypic diversity, including new genes that originated in recent evolution. In the past few years, substantial progress has been made in understanding the evolution and phenotypic effects of new genes. In particular, an emerging picture is that new genes, despite being present in the genomes of only a subset of species, can rapidly evolve indispensable roles in fundamental biological processes, including development, reproduction, brain function and behaviour. The molecular underpinnings of how new genes can develop these roles are starting to be characterized. These recent discoveries yield fresh insights into our broad understanding of biological diversity at refined resolution.
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