Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 4, Pages 227-232Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3185
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Funding
- NIGMS NIH HHS [R01 GM076536, DP1 GM106408] Funding Source: Medline
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Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented ability to survey mRNA and protein abundances. Such proteome-wide surveys are illuminating the extent to which different aspects of gene expression help to regulate cellular protein abundances. Current data demonstrate a substantial role for regulatory processes occurring after mRNA is made - that is, post-transcriptional, translational and protein degradation regulation - in controlling steady-state protein abundances. Intriguing observations are also emerging in relation to cells following perturbation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances. Here, we summarize current understanding of the major factors regulating protein expression.
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