Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 5, Pages 358-369Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3198
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Funding
- Damon Runyon-Rachleff Innovation Award
- Stand Up To Cancer Innovative Research Grant [SU2C-AACR-IRG1109]
- Prostate Cancer Foundation
- US National Institutes of Health [R01DK085714, P50 CA83636, 5 P30 CA015704, P50 CA97186]
- Department of Defense [PC074012, OC080159]
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MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of thousands of genes in a broad range of organisms in both normal physiological contexts and in disease contexts. miRNA expression profiling is gaining popularity because miRNAs, as key regulators in gene expression networks, can influence many biological processes and also show promise as biomarkers for disease. Technological advances have spawned a multitude of platforms for miRNA profiling, and an understanding of the strengths and pitfalls of different approaches can aid in their effective use. Here, we review the major considerations for carrying out and interpreting results of miRNA-profiling studies.
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