Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 3, Pages 175-188Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3114
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Funding
- Wellcome Trust
- UK Medical Research Council
- UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- MRC [G1001712] Funding Source: UKRI
- Medical Research Council [G1001712] Funding Source: researchfish
- National Institute for Health Research [CL-2006-13-003] Funding Source: researchfish
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Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence.
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