Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 5, Pages 315-328Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3187
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Funding
- Bill and Melinda Gates Foundation
- US National Institute of Allergy and Infectious Diseases
- US National Institutes of Health (NIH)
- Fogarty International Center at NIH
- Harvard Malaria Initiative
- Exxon Mobil Foundation
- SPARC
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Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.
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