Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 8, Pages 576-588Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3228
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Funding
- Canadian Institutes of Health Research
- Lady Davis Institute for Medical Research
- Ministere de Developpement economique, de l'Innovation et de l'Exportation du Quebec
- Arthritis Research Campaign
- Wellcome Trust
- Guy's & St. Thomas' NHS Foundation Trust
- King's College London Biomedical Centre
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Osteoporosis is among the most common and costly diseases and is increasing in prevalence owing to the ageing of our global population. Clinically defined largely through bone mineral density, osteoporosis and osteoporotic fractures have reasonably high heritabilities, prompting much effort to identify the genetic determinants of this disease. Genome-wide association studies have recently provided rapid insights into the allelic architecture of this condition, identifying 62 genome-wide-significant loci. Here, we review how these new loci provide an opportunity to explore how the genetics of osteoporosis can elucidate its pathophysiology, provide drug targets and allow for prediction of future fracture risk.
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