Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 1, Pages 47-58Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3129
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Funding
- US National Institutes of Health (NIH)
- Bill and Melinda Gates Foundation
- Crohn's and Colitis Foundation
- Howard Hughes Medical Institutes
- NIH [NIHU54HG004969]
- Crohn's and Colitis Foundation of America
- Juvenile Diabetes Research Foundation
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The human microbiome substantially affects many aspects of human physiology, including metabolism, drug interactions and numerous diseases. This realization, coupled with ever-improving nucleotide sequencing technology, has precipitated the collection of diverse data sets that profile the microbiome. In the past 2 years, studies have begun to include sufficient numbers of subjects to provide the power to associate these microbiome features with clinical states using advanced algorithms, increasing the use of microbiome studies both individually and collectively. Here we discuss tools and strategies for microbiome studies, from primer selection to bioinformatics analysis.
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