Journal
NATURE REVIEWS GENETICS
Volume 14, Issue 1, Pages 9-22Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3316
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Funding
- European Science Foundation through a European Young Investigators (EURYI) grant
- Netherlands Organisation for Scientific Research
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To understand genomic processes such as transcription, translation or splicing, we need to be able to study their spatial and temporal organization at the molecular level. Single-molecule approaches provide this opportunity, allowing researchers to monitor molecular conformations, interactions or diffusion quantitatively and in real time in purified systems and in the context of the living cell. This Review introduces the types of application of single-molecule approaches that can enhance our understanding of genome function.
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