Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 5, Pages 329-342Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg3174
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Funding
- US National Institutes of Health [R01GM099939, R01-HG004694]
- US National Science Foundation [IOS-1126998]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1126998] Funding Source: National Science Foundation
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The falling cost of genome sequencing is having a marked impact on the research community with respect to which genomes are sequenced and how and where they are annotated. Genome annotation projects have generally become small-scale affairs that are often carried out by an individual laboratory. Although annotating a eukaryotic genome assembly is now within the reach of non-experts, it remains a challenging task. Here we provide an overview of the genome annotation process and the available tools and describe some best-practice approaches.
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