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Understanding the transcriptome through RNA structure

Journal

NATURE REVIEWS GENETICS
Volume 12, Issue 9, Pages 641-655

Publisher

NATURE RESEARCH
DOI: 10.1038/nrg3049

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Funding

  1. US National Institutes of Health (NIH) [R01-HG004361]
  2. Agency of Science, Technology and Research of Singapore
  3. A.P. Giannini Foundation

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RNA structure is crucial for gene regulation and function. In the past, transcriptomes have largely been parsed by primary sequences and expression levels, but it is now becoming feasible to annotate and compare transcriptomes based on RNA structure. In addition to computational prediction methods, the recent advent of experimental techniques to probe RNA structure by high-throughput sequencing has enabled genome-wide measurements of RNA structure and has provided the first picture of the structural organization of a eukaryotic transcriptome - the 'RNA structurome'. With additional advances in method refinement and interpretation, structural views of the transcriptome should help to identify and validate regulatory RNA motifs that are involved in diverse cellular processes and thereby increase understanding of RNA function.

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