Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 1, Pages 56-68Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg2918
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Funding
- US National Institutes of Health (NIH) through Center of Excellence in Genomic Sciences (CEGS)
- NIH [HL061795, HL81587, HL70819, HL48743]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL048743, R21HL089734, R37HL061795, P01HL081587, R01HL061795, U54HL070819] Funding Source: NIH RePORTER
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Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that links tissue and organ systems. The emerging tools of network medicine offer a platform to explore systematically not only the molecular complexity of a particular disease, leading to the identification of disease modules and pathways, but also the molecular relationships among apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.
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